Hybrid Femtosecond Laser 3D Microfabrication: Reliable Tool for Fabrication of Functional Biochips

By Koji Sugioka

The rapid development of the femtosecond laser has revolutionized materials processing due to its unique characteristics of ultrashort pulse width and extremely high peak intensity. In particular, the high peak intensity allows nonlinear interactions such as multiphoton absorption and tunneling ionization to be induced in transparent materials, which provides versatility in terms of the materials that can be processed. More interestingly, irradiation with tightly focused femtosecond laser pulses inside transparent materials makes three-dimensional (3D) micro- and nanofabrication available due to efficient confinement of the nonlinear interactions within the focal volume.

Using this feature, subtractive manufacturing based on internal processing can realize the direct fabrication of 3D microfluidics, micromechanics, microelectronics and photonic microcomponents in glass. These microcomponents can be easily integrated in a single glass microchip by a simple procedure using a femtosecond laser to realize more functional microdevices, such as integrated biochips and photonic microdevices. Additive manufacturing based on multiphoton absorption (two-photon polymerization: TPP) enables the fabrication of 3D polymer micro- and nanostructures for photonic devices, micro- and nanomachines, and microfluidic devices, and has applications for biomedical and tissue engineering. Continue reading